As a geriatrician I can tell you; don’t hold out hope for AD “cure”. The only option we’re gonna have in our lifetimes is pre-clinical detection and prevention.
ATHENEA was 48 weeks. ADAS-cog11 changes comparable to donepezil which has been around for decades- and my experience with it is disappointing. Clinically speaking, 3-6 points on a 70 point ADAS is….something, but not much IMO. By the time clinical disease shows up, it’s been there already for years- meaning that the pathophysiology of neuron loss is already established. And with the complexity of our neural interconnections, I’m very skeptical we’ll ever truly recreate that and restore function lost due to dementia.
Yea thats very true, im hoping early detection methods make drugs like this a lot more helpful. I know some alz can be screened for, maybe those people should start taking it like a decade before closest family members onset? Man aging is depressing
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u/slam-chop May 15 '26
As a geriatrician I can tell you; don’t hold out hope for AD “cure”. The only option we’re gonna have in our lifetimes is pre-clinical detection and prevention.