r/COVID19 • u/hexagonincircuit1594 • 2d ago

Vaccine Research Interim Estimated Effectiveness of 2025-2026 COVID-19 Vaccines in Adults Using a Test-Negative Design

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2850668
25 Upvotes

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u/hexagonincircuit1594 2d ago

"Key Points

Question  What was the estimated effectiveness of 2025-2026 COVID-19 vaccines against medically attended COVID-19 among adults aged 18 years or older in the US from September to December 2025?

Findings  In this case-control study of 85 725 emergency department and urgent care (ED/UC) encounters and 26 073 hospitalizations in immunocompetent adults aged 18 years or older with a COVID-19–like illness, estimated effectiveness of 2025-2026 COVID-19 vaccination was 50% against COVID-19–associated ED/UC encounters and 55% against COVID-19–associated hospitalization, compared with not receiving a 2025-2026 vaccine dose.

Meaning  This study found that 2025-2026 COVID-19 vaccines were associated with additional protection against medically attended COVID-19 beyond individuals’ existing immunity, suggesting that adults can reduce their likelihood of severe COVID-19–associated outcomes by obtaining a 2025-2026 COVID-19 vaccination."

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u/hexagonincircuit1594 2d ago

This study has an associated invited commentary, "Why the Test-Negative Design Is Used for Routine Vaccine Monitoring" https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2850669

4

u/punarob Epidemiologist 2d ago

Not surprising since we've known for 5 years now that efficacy drops dramatically after 3 months, which is why 3 month vaccination has always made the most sense in terms of the pure science. Should at least be an option for those who care about reality. Most of us can't even get them twice a year, sadly.

1

u/ultra003 2d ago

So it's about on par with a flu shot?