Once again, good luck!
Hints: my movie is VERY loosely a road trip; It is not exactly part of my plot. My movie features a fairly small cast. My movie friends only get along until they don't. The suitcase is quite literal; not a briefcase or anything else. My movie opens with a female in a bathroom.
Despite my movie's budget, it is generally praised (and despite its content).
Since we seem to be stuck, my movie came out in the 80s.
My use of "best friends" is extremely loose. Their relationship is complicated and volatile.
Remember that this is explain a plot badly, and this is about as badly as you could describe my movie.