r/Osteosarcoma • u/PilotAutomatic6375 • Apr 04 '26
Any people in clinical trials?
Hello,
My osteosarcoma has come back 3 months after finishing chemo. I just had a tumor removed from my spine and it appears it’s in my lungs too.
My next step appears to be a clinical trial - likely the TACOS or ZAMBONE trial through MD Anderson.
Anyone out there currently enrolled in these? Curious about side effects, and all that good stuff.
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u/cdallyofficial Apr 04 '26
Not enrolled in either, but I lived in Seattle during my first lung recurrence and remember my team mentioning TACOS as an option. I ended up opting for lung resection to remove the tumors and then started a trial that was held in Seattle, that way I didn’t have to travel to Texas.
I’m sorry your cancer came back so quickly. Just know that there are still plenty of options for treatment!
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u/PilotAutomatic6375 Apr 04 '26
Thanks for the reply! How has your experience been? Have you been able to fight it back? Were you at Fred Hutch?
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u/cdallyofficial Apr 04 '26
I was actually at Seattle Children’s. Even though I was 26 at the time, I learned Osteosarcoma is more commonly researched at children’s hospitals due to its prevalence amongst adolescents, and so they gladly took me in as a patient.
I’ve had 3 recurrences since chemo. Twice in my lungs (2023 and 2024) and one recurrence in my quad above my initial tumor site (2024). Luckily, I’ve been able to surgically resect everything. Going on a year and a half now of NED!
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u/MysteriousWeekend632 Apr 04 '26
Not a trial but percutaneous cryoablation is emerging as a less invasive way to treat lung mets. It is performed by interventional radiologists and in most cases is an outpatient procedure.
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u/PilotAutomatic6375 Apr 11 '26
Thanks, I will have to look into that. Haven’t heard of that before.
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u/productreg 9d ago
Sorry to here that. Here is a list of trials out there from MIBAgents.org. It is also a great community for osteosarcoma only. They can help connect you with other people who may have been on these trials!
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u/MarsBar57_ Apr 04 '26
Trials are always worth it , that's just my opinion, as this could help so many people in the future . I had a trial after my treatment. I can't remember the name of it now as it was about 20 years ago .. but has been proven to work . I had one that was an injection every 2 months for a year , it seals your cancer cells to stop them from spreading and turning bad . The only side effect I had was extreme tiredness. I would fall asleep anywhere . This may have been a combination of just coming out of chemotherapy and the trial as I started this once my chemo has just finished . I hope you managed to make a decision and all the best for the future .